Metabolic Control of Creatine Biosynthesis
نویسندگان
چکیده
منابع مشابه
Metabolic control of creatine biosynthesis. II. Restoration of transamidinase activity following creatine repression.
In recent years, two novel metabolic control mechanisms have been discovered in unicellular organisms (cf. 1, 2). Both mechanisms employ the negative feedback principle, in which input is regulated by output. Each of these feedback controls is most effective when it operates on the first enzyme of a biosynthetic sequence. In the first type of control, the ultimate end product of the biosyntheti...
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Recent observations in two patients, one with AGAT deficiency (AGAT-D) and one with GAMT deficiency (GAMT-D), both diagnosed already at birth, provide first evidence for important therapeutic effects of pre-symptomatic treatment with creatine (Cr) supplementation in AGAT-D and Cr supplementation plus guanidinoacetate lowering strategies in GAMT-D. Although long-term data are lacking, the result...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1961
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64390-x